Reimagine your downstream purification with Smart Polymers™
Synthetic affinity ligands delivering high recovery, high purity and cost-effective manufacturing.
Synthetic affinity ligands designed for bioprocessing challenges
Smart Polymers™ are a new generation of synthetic affinity ligands, designed to deliver the binding characteristics required for specific bioprocessing challenges. Our platform enables the rapid design, manufacture and optimisation of polymer ligands, from off-the-shelf purification solutions to custom ligand development for challenging bioprocessing applications.
Smart Polymers™ for viral vector purification
Downstream processing can be a major source of viral vector loss, contributing to the current restrictive costs of advanced therapies. Tozaro is developing Smart Polymer™ ligands to enable efficient, scalable purification of Lentivirus and AAV.
Lentivirus purification ligands
VSV-G-targeting Smart Polymers™ have been demonstrated across bead, membrane and monolith formats, delivering >50% functional recovery and >99% HCP and residual DNA removal, directly from harvest.
AAV purification ligands
Early analysis of pan-serotype AAV Smart Polymers™ has demonstrated binding and elution performance comparable to leading purification ligands across AAV serotypes 1, 2, 5, 6 and 9, with further screening ongoing.
Access The Smart Polymer™ Platform
The Smart Polymer™ Platform combines computational design and machine learning with chemical manufacture to create affinity ligands tailored to the target and application.
It can be applied to multiple targets for custom development including viral vectors, cells, recombinant proteins, complex antibodies and more.
Why Smart Polymers?
Until now, affinity chromatography has relied on conventional biological ligands such as antibodies and peptides. But with lengthy discovery times, high development costs, sensitivity to degradation and limited control over binding characteristics, an alternative has been overdue. Smart Polymers™ tackle these major challenges, offering the bioprocessing industry high performing, cost effective alternative to biological affinity ligands.
Behind the Batch Podcast
In the first episode of Behind the Batch, a Tozaro original series, our host Alex Shepherd chats with Andre Raposo, Senior Director of Innovation at OXB. Andre shares his journey from fundamental HIV research to leading innovation in viral vector manufacturing at OXB. The pair explore the integration of automation, AI, and data-driven approaches in cell and gene therapy development, along with lessons learned from failures and successes.
Collaborate with us
We believe collaboration is key to overcoming complex manufacturing challenges at pace. We work with Biotech’s, CDMO’s and academia to develop next-gen purification solutions for advanced therapies and beyond.