Novel synthetic affinity reagents for lentivirus analytics and capture chromatography – Presented at The Bioprocessing Summit 2024

First presented at The Bioprocessing Summit 2024, this poster introduces a new suite of synthetic affinity reagents targeting VSV-G, a lentivirus envelope protein for viral vector analytics and purification.

Smart polymers targeting VSV-G accurately detect lentivirus in Octet® BLI platform and show promise for novel capture chromatography

These synthetic affinity reagents have been designed to increase the performance of lentiviral based processes in analytics and purification. Smart polymer analytical performance was demonstrated on the Octet®  biolayer interferometry (BLI) platform. A bind-and-release mechanism was demonstrated in a prototype purification set-up, indicating the possibility to go beyond analytics and vastly improve lentivirus yields during downstream processing. Download the full poster today.