Moving Closer to Affordable Advanced Therapies: A Review of Current Trends in Downstream Processing

Originally published in International Biopharmaceutical Industry Journal, Volume 7, Issue 4.

Tozaro’s Head of Cell and Gene Therapy Applications, Abdullah Sufan, discusses the latest trends shaping downstream processing and the technologies helping to make advanced therapies more affordable and scalable. This review explores the evolving landscape of viral vector purification, highlighting emerging approaches that can reduce manufacturing costs, improve process efficiency, and support the wider adoption of cell and gene therapies.

Key topics covered include:

• The downstream processing challenges limiting the scalability of advanced therapies.
• Current approaches to viral vector purification for gene therapy and vaccine manufacturing.
• Emerging affinity-based technologies and novel purification strategies.
• How process innovation can reduce manufacturing costs while improving quality.
• The future direction of downstream processing for more affordable advanced therapies.