No Llamas, No Lottery: How Tozaro Is Using Octet® BLI and Smart Polymers™ to Rethink Viral Vector Purification

In this interview with Sartorius, Dr Emma Daniels, Tozaro’s Head of Development Chemistry, explains how Tozaro has integrated Smart Polymers^TM into Octet® Bio-Layer Interferometry (BLI) to develop new approaches to viral vector analytics.

Discover how computational design, synthetic affinity ligands and rapid screening are helping Tozaro address key challenges in AAV and lentiviral manufacturing, from improving functional recovery and impurity removal to developing faster, more targeted quantification methods.

In this article:

• How Smart Polymers™ are designed and tailored for purification and analytical applications.
• How Octet® BLI accelerates polymer screening and optimisation compared with traditional approaches.
• Early results in lentiviral purification, including functional recovery and impurity reduction.
• The potential for synthetic affinity reagents to support more efficient, robust and cost-effective viral vector manufacturing.