Technical posters
Read through our latest technical posters to discover more about Tozaro’s affinity ligands
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Development of VSV-G Smart Polymers for Lentivirus Quantification: from in silico modelling to application
Novel, high affinity ligands for VSV-G were rapidly generated and screened using proprietary in silico modelling and solid phase imprinting. Within 12 weeks of initial modelling, 3 novel polymers were produced and successfully used to quantify lentivirus titer using the Octet BLI from Sartorius.
Novel synthetic affinity reagents for lentivirus analytics and capture chromatography
Presented at The Bioprocessing Summit 2024
Synthetic VSV-G affinity ligands show functionality when integrated into lentivirus analytical and purification methods. Polymers successfully capture and release lentiviral surrogates under mild elution conditions, demonstrating their potential use in capture chromatography.
Developing new tools for rapid quantification of viral vectors – a proof of concept
Presented at Advanced Therapies 2024
Tozaro first realized the potential of rationally designed polymers for viral quantification and purification while working on gp120 (HIV virus envelope glycoprotein) in collaboration with the Bill and Melinda Gates Foundation. This was done using a combination of proprietary molecular modelling and a patented chemical synthesis process to generate novel gp120 specific polymers.
Affinity enrichment and femtomole detection of spike protein using smart polymers
This research poster LC-MS Detection of SARS-Cov2 Spike Protein using Smart Polymers emphasises the possibility of using smart polymers for viral purification.
