Smart Polymer™ ligands are synthetic affinity binders designed to selectively capture adeno-associated virus (AAV) particles during downstream processing. They are being developed as an alternative to traditional purification methods used in AAV purification workflows.

A pan-serotype AAV purification ligand is designed to recognise and bind multiple AAV serotypes rather than a single serotype. This can simplify process development by reducing the need to develop separate purification strategies for each AAV programme.

To date, Tozaro’s pan-serotype Smart Polymer™ ligands have been evaluated against AAV1, AAV2, AAV5, AAV6 and AAV9. Additional serotype testing is currently ongoing as part of the ligand development programme. 

Tozaro is currently working with partners to integrate AAV Smart Polymer™ ligands onto commercially relevant purification formats including membranes, monoliths and beads.

The AAV Smart Polymer™ programme is currently in development. Tozaro is actively validating performance across multiple serotypes and working with partners to evaluate deployment formats and manufacturing pathways.

Yes. Tozaro is seeking collaborations with CDMOs, biopharmaceutical companies, technology providers and downstream processing specialists interested in evaluating or integrating Smart Polymer™ technology into AAV manufacturing workflows.