Traditional affinity ligands are typically discovered through biological screening processes and produced using biological manufacturing systems. Smart Polymers™ are designed in silico utilizing machine learning and manufactured synthetically, providing greater control over binding and elution characteristics, faster development timelines and lower manufacturing costs. The platform also enables the design of binders with application-specific affinity profiles … Continued

Smart Polymers™ can be developed for a wide range of bioprocessing applications, including viral vector purification, complex antibody purification, recombinant protein purification, DNA and RNA capture, vaccine manufacturing, cell separation and analytical assays. Because the platform is target-driven, it can be adapted to many different biological molecules and therapeutic modalities.

The Smart Polymer™ Platform begins with computational analysis of the target molecule to identify optimal binding regions. A large, proprietary library of polymer building blocks is then screened in silico to identify candidate binders, with designs refined by machine learning. Selected candidates are synthesized and experimentally validated, enabling rapid development of application-specific affinity reagents.

Synthetic affinity binders such as Smart Polymers™ offer several potential advantages, including scalable, cost-effective chemical manufacturing, reduced reliance on biological production systems, faster development timelines and the ability to engineer binding and elution characteristics for specific applications. They may also provide improved supply chain resilience compared with biologically derived affinity reagents.

Using Tozaro’s Smart Polymer™ Platform, candidate binders can typically be identified within approximately one month. This accelerated development process is achievable because of the powerful computational design element of the platform.

No. While the first applications focus on AAV and lentiviral vector purification, Smart Polymer technology is a platform technology that can be applied across multiple areas of bioprocessing. Potential future applications include complex antibodies, proteins, nucleic acids, vaccines and rapid analytics.

Smart Polymer™ technology has potential applications across biotechnology, pharmaceutical manufacturing, cell and gene therapy, vaccine development, diagnostics and life science research. Any process requiring selective molecular recognition, purification or capture could potentially benefit from custom-designed Smart Polymer™ binders.

Tozaro has built a portfolio of intellectual property around its Smart Polymer™ Platform, including the design, composition and application of Smart Polymer™ binders for bioprocessing and life science applications.

The cost of a Smart Polymer™ solution depends on the specific application and the format in which the binder is deployed, such as chromatography resins, beads, membranes or monoliths. However, as Smart Polymers™ are manufactured using scalable chemical synthesis rather than biological production systems, they have the potential to offer significant cost advantages compared with … Continued

Tozaro develops and manufactures its Smart Polymers™ under an ISO 9001-certified Quality Management System, with processes designed to support use in regulated bioprocessing applications. Our manufacturing follows GMP-compatible practices, including documented procedures, batch traceability and quality control testing to ensure consistent product quality and performance.