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Behind the Batch Episode 3 – Jay Rosanelli

By M T

In episode 3 of Behind the Batch, our host Alex Shephard chats with Jay Rosanelli, Co-Founder and CEO of Syenex. He discusses his move from neuropharmacology research into investment banking and then into founding a biotech built around targeted delivery technologies for genetic medicines, covering the technical failures along the way, the realities of raising … Continued

BioProcess International 2026 – Rewriting Bioprocessing with Synthetic Affinity Ligands

By M T

In this presentation from BioProcess International 2026, Alex Shephard, Tozaro’s Head of Product, explores how Smart Polymer™ technology can address some of the key challenges in viral vector downstream processing. Discover how Tozaro’s computationally designed synthetic affinity ligands offer a new approach to purification, combining target specificity and tunable binding affinity with the potential for … Continued

No Llamas, No Lottery: How Tozaro Is Using Octet® BLI and Smart Polymers™ to Rethink Viral Vector Purification

By M T

In this interview with Sartorius, Dr Emma Daniels, Tozaro’s Head of Development Chemistry, explains how Tozaro has integrated Smart PolymersTM into Octet® Bio-Layer Interferometry (BLI) to develop new approaches to viral vector analytics. Discover how computational design, synthetic affinity ligands and rapid screening are helping Tozaro address key challenges in AAV and lentiviral manufacturing, from … Continued

Rationally Designed Smart Polymers for Affinity Purification of AAV and Lentiviral Vectors – Presented at BioProcess International 2025

By M T

Presented by Alex Shephard at BioProcess International 2025 (BPI), this poster introduces Smart PolymersTM developed for the selective capture, release, and purification of lentiviral vectors. Read how the polymers were immobilized on a membrane and used to purify lentiviral samples via the AKTA FPLC. The work demonstrated recovery of >60% along with excellent purity profiles, … Continued

Moving Closer to Affordable Advanced Therapies: A Review of Current Trends in Downstream Processing

By M T

Originally published in International Biopharmaceutical Industry Journal, Volume 7, Issue 4. Tozaro’s Head of Cell and Gene Therapy Applications, Abdullah Sufan, discusses the latest trends shaping downstream processing and the technologies helping to make advanced therapies more affordable and scalable. This review explores the evolving landscape of viral vector purification, highlighting emerging approaches that can … Continued

Behind the Batch Episode 2 – Giuliana Vallanti

By M T

Behind the Batch spotlights the moments that shape the people pioneering cell and gene therapy. Failed batches, first viable runs, tech transfers, and everything in between. In episode 2, our host Alex Shephard chats with Giuliana Vallanti, SVP Operations and R&D at AGC Biologics. She discusses two decades in cell and gene therapy, from process … Continued

Rewriting Bioprocessing with Synthetic Affinity Ligands – Presented at Bioprocessing Summit 2026

By M T

First presented at The Bioprocessing Summit 2026, this poster introduces a platform of synthetic Smart PolymersTM, rationally designed as affinity ligands for the selective capture, release, and purification of AAV and lentiviral vectors. These reagents are engineered to enable serotype-specific or pan-serotype binding, with tunable affinity for both purification and analytical use.