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Rationally Designed Smart Polymers for Affinity Purification of AAV and Lentiviral Vectors – Presented at BioProcess International 2025

By M T

Presented by Alex Shephard at BioProcess International 2025 (BPI), this poster introduces Smart PolymersTM developed for the selective capture, release, and purification of lentiviral vectors. Read how the polymers were immobilized on a membrane and used to purify lentiviral samples via the AKTA FPLC. The work demonstrated recovery of >60% along with excellent purity profiles, … Continued

Moving Closer to Affordable Advanced Therapies: A Review of Current Trends in Downstream Processing

By M T

Originally published in International Biopharmaceutical Industry Journal, Volume 7, Issue 4. Tozaro’s Head of Cell and Gene Therapy Applications, Abdullah Sufan, discusses the latest trends shaping downstream processing and the technologies helping to make advanced therapies more affordable and scalable. This review explores the evolving landscape of viral vector purification, highlighting emerging approaches that can … Continued

Behind the Batch Episode 2 – Giuliana Vallanti

By M T

Behind the Batch spotlights the moments that shape the people pioneering cell and gene therapy. Failed batches, first viable runs, tech transfers, and everything in between. In episode 2, our host Alex Shephard chats with Giuliana Vallanti, SVP Operations and R&D at AGC Biologics. She discusses two decades in cell and gene therapy, from process … Continued

Rewriting Bioprocessing with Synthetic Affinity Ligands – Presented at Bioprocessing Summit 2026

By M T

First presented at The Bioprocessing Summit 2026, this poster introduces a platform of synthetic Smart PolymersTM, rationally designed as affinity ligands for the selective capture, release, and purification of AAV and lentiviral vectors. These reagents are engineered to enable serotype-specific or pan-serotype binding, with tunable affinity for both purification and analytical use.

Behind the Batch Episode 1 – Andre Raposo

By M T

Behind the Batch spotlights the moments that shape the people pioneering cell and gene therapy. Failed batches, first viable runs, tech transfers, and everything in between. In episode 1, our host Alex Shephard chats with Andre Raposo, Senior Director of Innovation about his journey from fundamental HIV research to leading innovation in viral vector manufacturing … Continued

Novel synthetic affinity reagents for lentivirus analytics and capture chromatography – Presented at The Bioprocessing Summit 2024

By Keli

First presented at The Bioprocessing Summit 2024, this poster introduces a new suite of synthetic affinity reagents targeting VSV-G, a lentivirus envelope protein for viral vector analytics and purification. Smart polymers targeting VSV-G accurately detect lentivirus in Octet® BLI platform and show promise for novel capture chromatography These synthetic affinity reagents have been designed to … Continued